${MARK_SM} Built with Claude · Life Sciences

Read the evidence.
Draft the verdict.

Norn is a variant-interpretation copilot. It drafts ACMG/AMP evidence for a human curator to confirm.

${MARK_MD}Norn
NOT FOR CLINICAL USE
${MARK_SM} What Norn is

Gather, weigh, decree.

Paste one variant. Norn gathers public genomics evidence, adjudicates each ACMG criterion with Claude, and computes a transparent classification.

Urðr what was
Gather

Consequence, frequency, and neighbor evidence from Ensembl VEP, gnomAD v4, and ClinVar.

Verðandi what is
Weigh

Claude adjudicates each criterion against code-computed signals, with reasoning.

Skuld what shall be
Decree

The ClinGen points framework combines the verdicts in code. The engine owns the label.

${MARK_SM} One principle

The model justifies. The engine decides.

Claude returns a per-criterion verdict with reasoning; it never returns the final label. The classification is always computed in code, so the same evidence yields the same call.

${BEAD('recode')}
${BEAD('VEP')}
${BEAD('gnomAD')}
${BEAD('ClinVar')}
${BEAD('adjudicate')}
${BEAD('review')}
${MARK_MD}Norn
${MARK_SM} A drafted interpretation

Transparent, sourced, yours to confirm.

BRCA1:c.5266dupCLikely Pathogenic
ACMG POINT AGGREGATION+9 pts
BenignLikely benignVUSLikely path.Pathogenic

PVS1 (+8) frameshift, PM2 (+1) absent from gnomAD. PM2 is applied at supporting strength, so a classic loss-of-function variant lands at Likely Pathogenic on automated evidence alone.

${MARK_SM} Norn

Spend your time confirming,
not gathering.

Live demo: norn-five.vercel.app · Repo: github.com/vignesh-nagarajan-vn/Norn

${MARK_MD}Norn
NOT FOR CLINICAL USE