A variant-interpretation copilot. Paste one variant; Norn gathers the evidence, adjudicates each ACMG/AMP criterion with Claude, and drafts a classification to confirm.
The Norse fates read evidence and decree fate. Norn reads the evidence; a human decides.
Named for the Norse fates who weave destiny, Norn follows the same three movements.
Consequence, frequency, and neighboring-residue evidence from Ensembl VEP, gnomAD v4, and ClinVar.
Claude adjudicates each ACMG/AMP criterion against code-computed signals, one line of reasoning each.
ClinGen points combine the verdicts in code. The engine owns the label; the model only justifies it.
Interpretation only. Norn also has a Batch worklist and an Evaluation benchmark.
Norn gathers the evidence, weighs each criterion with Claude, and the engine decrees the classification.
Claude returns a per-criterion verdict and one line of reasoning, never the final label.
The engine computes the classification in code, so the same evidence always yields the same call. A second Claude pass then critiques the draft and writes the curator checklist.
Every interpretation is interactive, not a black-box label.
Every point is sourced, and a second Claude pass flags overcalls.
Frameshift in a loss-of-function-intolerant gene.
+8Absent from gnomAD v4.
+1A preview. PM2 at supporting strength keeps a loss-of-function variant at Likely Pathogenic on automated evidence alone. Open the Dashboard to run a real one.
Each stage streams live and lights up as it completes.
A row per criterion with strength, verdict, evidence, and source, plus a points meter.
Toggle the eight evidence-dependent criteria; the classification recomputes live.
The query plotted against nearby ClinVar variants, colored by class.
Question the call; Claude answers from that report alone.
A PubMed search surfaces functional and case evidence for the gene and change.
Paste a list or upload CSV or VCF to interpret many variants into a worklist.
The same pipeline over stdio, so other tools can import Norn's output.
Manual first-pass triage of one variant can take 20 to 40 minutes; Norn produces that sourced draft in about a minute. It drafts; you decide, never an autonomous diagnostic.