Evaluation
Norn runs its full pipeline on a set of well-established variants and compares its call to the expected ClinVar label, by exact five-tier agreement and by directional concordance. Each is also adjudicated by the deterministic heuristic on the same evidence, so you can see what Claude's reasoning adds over rules alone.
Anti-circularity: a variant's own ClinVar classification is never fed into adjudication. ClinVar is used only for neighboring-residue evidence (PS1, PM5). The expected label here is the comparison target, not an input to the engine.
Variants
0
Evaluated
0
Live directional
n/a
Heuristic directional
n/a
| Variant | Gene | Expected | Norn | Heuristic | Points | Match |
|---|
Norn implements ten automated criteria and applies PM2 at supporting strength, so it is deliberately conservative: many true-pathogenic variants land at Likely Pathogenic, not Pathogenic. Exact agreement runs lower than directional concordance, the more meaningful measure for triage. Disagreements are shown, not hidden.